Let's precede to the plot of the story.

First of all, from the point of view of presentation, the story is the third person narrative with the elements of a dialogue.

Secondly,the story has a closed plot structure and it runs as follows: the esposition (from the words "in a little district" till the words "the joint studio resulted"), the story itself (from the words "that was in May" till the words "around her, pillows and all" till the words "through an icy cold"), the climax (from the words "They couldn't imagine" till the words "ivy leaf on the wall"), the denouement (from the words "didn't you wonder" till the words "the last leaf fell").

As for the story itself, it tells us about two young women artists, Sue and Johnsy (familiar for Joanna). They met in May, six months previously, and decided to share a studio apartment. Stalking their artist colony in November is "Mr. Pneumonia." The story begins as Johnsy, near death from pneumonia, lies in bed waiting for the last leaf of an ivy vine on the brick wall she spies through her window to fall.

"I’m tired of thinking," says Johnsy. "I want to turn loose my hold on everything, and go sailing down, down, just like one of those poor, tired leaves". However, an unexpected hero arrives to save Johnsy. It’s not the brusque doctor who gives her only one in ten chances to survive, raising them to one in five if Sue can get her to hope for something important like a man, not her true desire to "paint the Bay of Naples some day" .

Mr. Behrman, an old man who lives in the apartment below Sue and Johnsy, who enjoys drinking, works sometimes as an artist’s model, and as yet has made no progress over the past 40 years on painting his own masterpiece, becomes in typical O. Henry fashion the hero. The evidence of his heroics are found the day before he dies from pneumonia: outside Johnsy’s window are a ladder, a lantern still lighted "some scattered brushes, and a palette with green and yellow colors mixed on it . . . it’s Behrman’s masterpiece--he painted it (a leaf) there the night that the last leaf fell", Sue informs Johnsy.